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. 2019 Oct 2;9:14159. doi: 10.1038/s41598-019-50335-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Kinome-wide selectivity of JAK kinase inhibitors determined by kinobeads experiments using PBMC lysate. (a) Heatmap displaying all competed kinases from kinobeads experiments. Experiments were done in duplicate using two different concentration ranges; displayed value is mean of calculated apparent pK_ds. Only kinases are displayed for which at least one inhibitor showed an apparent pK_d above 6.5 (b) Potency windows (delta apparent pK_d) between the most potently hit JAK kinase (set as reference) to all other competed kinases for all investigated JAK kinase inhibitors. JAK kinases are marked in red, all other kinases are marked in blue. (c) Distribution of all identified JAK kinase inhibitor off-targets over the kinome tree. (see also Supplementary Table 7).