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. 2019 Oct 2;9:14215. doi: 10.1038/s41598-019-50794-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Strong relationships between the hedgehog pathway and six target genes are found. GSEA and ssGSEA analysis showing the relationships between the hedgehog pathway and six target genes. GSE32062 contains 260 patients with ovarian cancer. GSE9891 contain 285 patients with ovarian cancer. (a) Results of GSEA analysis. Enrichment score (ES) and FDR q value (FDR q) are shown. Red shading indicates significant enrichment for sh-target genes at an FDR q < 0.25. (b) Results of correlation analysis between the scores of the six gene signature and the hedgehog pathway-related signature. Red shading indicates a significant positive correlation (p < 0.05) and blue shading indicates a significant negative correlation (p < 0.05).