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. 2019 Oct 2;9:14175. doi: 10.1038/s41598-019-50481-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Serum AP activity at baseline, following cannulation to cardiopulmonary bypass, at rewarming, and at euthanasia. Comparisons for differences in mean serum AP activity between interventional groups at each time point are presented. CPB/DHCA = cardiopulmonary bypass with deep hypothermic circulatory arrest; AP = alkaline phosphatase; * p < 0.005 versus anesthesia controls; # p < 0.01 versus CPB/DHCA and CPB/DHCA + AP low; & p < 0.05 versus anesthesia controls; α p < 0.05 vs CPB/DHCA + AP low; β p < 0.01 versus anesthesia controls; χ p < 0.05 versus CPB/DHCA; δ p < 0.05 versus CPB/DHCA; Δ p < 0.05 versus CPB/DHCA + AP high.