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. 2019 Oct 2;9:14230. doi: 10.1038/s41598-019-50652-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) In non-decidualized endometrium, the stroma is podoplanin-negative and contains many lymphatic vessels (arrow). Lymphatic regression is prominent in decidualized endometrium (asterisk indicates lymphatic vessels) (podoplanin, a ×50). (b) Strong expression of podoplanin in decidual cells around spiral arterioles (arrow, spiral arteriole; asterisk, podoplanin-positive decidual cell) (podoplanin, ×400). (c) Cytoplasmic podoplanin immunoreactivity in Hofbauer cells (asterisk) and apical immunoreactivity in syncytiotrophoblasts (arrow) (podoplanin, ×200). (d) Membranous podoplanin immunoreactivity in decidual cells (arrow) (podoplanin, ×100). (e) Loss of podoplanin expression in areas of stromal fibrosis (asterisks) in chorionic villi (podoplanin, ×200). (f) Podoplanin-positive stromal cells laying cisterns in molar villi (arrow) (podoplanin, ×630).