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. 2019 Oct 2;9:14185. doi: 10.1038/s41598-019-50726-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Ultrastructural analysis of storage material in the retina of Ppt1 ko mice. Low-power electron micrographs depict the different layers of a 240-day-old wild-type (a–c) and age-matched Ppt1 ko retina (f–h). Analyses of the boxed areas in (f–h) at higher magnification revealed the presence of granular osmiophilic deposits in subretinally located macrophages (arrowheads in i), retinal interneurons (asterisks in j) and retinal ganglion cells (asterisks in k) respectively of Ppt1 ko retinas. Similar cytoplasmic inclusions were not detectable in retinas of age-matched control mice (d,e). gcl: ganglion cell layer; inl: inner nuclear layer; ipl: inner plexiform layer; onl: outer nuclear layer; os: outer segments. Scale bar in (h) (for a–c,f–h): 5 μm; in (i): 1 μm; in (k) (for d,e,j,k): 0.2 μm.