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. 2019 Oct 2;9:14185. doi: 10.1038/s41598-019-50726-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Degeneration of various retinal cell types in PPT1-deficient mice. The density of PNA-labelled cone photoreceptor cells, BRN-3A-positive retinal ganglion cells, PKCα-positive rod bipolar cells and SCGN-positive cone bipolar cells in 45-day-old Ppt1 ko retinas (b,f,j,n, respectively) was similar to that observed in wild-type retinas (a,e,i,m, respectively). Retinas from 112-day-old Ppt1 ko mice also contained normal numbers of retinal ganglion cells (g) and rod bipolar cells (k), but decreased densities of cone photoreceptor cells (c) and cone bipolar cells (o). Note the significant decrease in the number of all cell types in 240-day-old mutant retinas (d,h,l,p) when compared to age-matched wild-type retinas (a,e,i,m). gcl: ganglion cell layer; inl: inner nuclear layer; ipl: inner plexiform layer; onl: outer nuclear layer. Scale bar in (p) for (a–p): 100 µm.