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. 2019 Sep 26;10:1127. doi: 10.3389/fphar.2019.01127

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Copyright © 2019 von Gundlach, Ashby, Gani, Lopez-Perez, Cookson, Ann Huws, Rumancev, Garamus, Mikut, Rosenhahn and Hilpert

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The linear coefficients of the first two principle components discriminate morphological changes and modes of action. The color decodes the bacterial species, the symbol the applied treatment, and the symbol thickness the incubation time. The error estimate is calculated from duplicate measurements and found to be 0.24 for the coefficient of PC1 and 0.10 for the coefficient of PC2. The transmission electron micrographs at a 15,000 times magnification show MRSA left and Escherichia coli right hand side. Top row shows untreated cells; middle row, treatment with 14D; and lower row, treatment with 69D. Peptide treatment time was 40min.