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Tacrolimus dose requirement (mg/kg body weight/day) for the entire observation period of 16 days after transplantation for CYP3A5*3, CYP3A4/CYP3A5 combined genotypes, and CYP3A4*22. Dots represent medians of tacrolimus dose/body weight at the different days; shaded areas are defined by 25 and 75% quantiles. Significance levels are shown as asterisk: *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.
