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. 2019 Sep 26;10:871. doi: 10.3389/fgene.2019.00871

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Copyright © 2019 Abdel-Kahaar, Winter, Tremmel, Schaeffeler, Olbricht, Wieland, Schwab, Shipkova and Jaeger

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Box-scatter plots per day of tacrolimus trough levels measured using liquid chromatography with tandem mass spectrometry. Thick lines represent median levels, boxes represent the interquartile range from 25 and 75% percentiles, and whiskers extend from the 25 or 75% percentile to the highest (or lowest, respectively) value not further than 1.5 times the interquartile range. The supra-therapeutic level of 15 ng/ml is shown using a horizontal dashed line. (B) Median tacrolimus trough levels according to CYP3A4/5 combined genotype (EM, extensive metabolizer; IM, intermediate metabolizer, PM, poor metabolizer). Dots represent the medians per day, while shaded areas are defined by 25 and 75% quantiles. Levels below 6 ng/ml are considered to be subtherapeutic. Significance levels are shown as asterisk: ***P < 0.001.