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. 2019 Sep 26;13:57. doi: 10.3389/fncir.2019.00057

FIGURE 2.

FIGURE 2

Differences in correlations of network activity between Fmr1 KO mice and wild type littermates can be explained by changes in L- and H-type activity patterns. (A) Mean pairwise correlations binned for inter-neuronal distance in Fmr1 KOs, wild types, and wild types adjusted for L/H-event ratios. In Fmr1 KOs correlations were increased across all distance bins. Randomly deleting L-events from wild type activity patterns to mimic the reduced L/H-event ratio in KOs compensated the difference fully. (B) Correlations differed significantly when all events were compared (∗∗p = 0.002, Wilcoxon rank sum test), but were indistinguishable between Fmr1 KO and wild type when activity events were separated into L- and H-events. (C) When matching the L/H-event ratios between Fmr1 KOs and wild type animals, correlations became virtually identical (Fmr1 KO data is from B, “All”, for comparison).