Figure 2.

MSC-derived exosomes alleviated lung injury induced by intestinal ischemia reperfusion. Representative histologic appearance of lung tissue from: (A) SHAM group; (B) IIR group; (C) MSC group and (D) MSC-EX group 20 h after reperfusion following 75 min of intestinal ischemia (HE stained) (magnification×100). Bar graphs in (E), (F) and (G) display lung histological scores, wet/dry ratio and MPO activity, respectively. The data represent means ± standard deviation. n = 8 independent experiments. P values < 0.05 were considered statistically significant. * indicates p < 0.05 compared with SHAM group, # indicates p < 0.05 compared with IIR group. (H) Cleaved caspase-3 protein levels in lung assessed by Western blot analysis.