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. 2019 Sep 26;10:2198. doi: 10.3389/fimmu.2019.02198

Figure 3.

Figure 3

Effects of single administrations of CXCL1, CXCL2, and CXCL3 (A–F) on nociceptive transmission in naive mice. The effects of single intrathecal administrations of CXCL1, CXCL2, CXCL3 (2, 400, or 800 ng/5 μl) on mechanical hypersensitivity (von Frey test, A–C) and thermal hypersensitivity (cold plate test, D–F) were measured at 1.5, 5, and 24 h after administration. Data are presented as the means ± SEM (6 mice per group). The results were evaluated using one-way ANOVA, followed by Bonferroni's test for comparisons of selected pairs measured separately at each time point. *p < 0.05, **p < 0.01, ***p < 0.001 for the comparison of vehicle-treated naive animals with all groups at the indicated time points. Additionally, the results were evaluated using two-way ANOVA to determine the time × drug interaction (please see results in Chapter 3.3). V, vehicle.