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. 2019 Sep 26;10:2198. doi: 10.3389/fimmu.2019.02198

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Copyright © 2019 Piotrowska, Rojewska, Pawlik, Kreiner, Ciechanowska, Makuch, Nalepa and Mika.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of single administrations of CXCL3 neutralizing antibody (A,B) on nociceptive transmission in CCI-exposed mice. The effects of single intrathecal administrations of CXCL3 neutralizing antibody (1, 4, or 8 μg/5 μl) on mechanical hypersensitivity (von Frey test, A) and thermal hypersensitivity (cold plate test, B) were measured at 1.5, 5, 24, and 48 h after administration at 7 days after CCI. Data are presented as the means ± SEM (6–8 mice per group). The results were evaluated using one-way ANOVA followed by Bonferroni's test for comparisons of selected pairs. *p < 0.05, **p < 0.01, ***p < 0.001 for the comparison of CCI-exposed vehicle-treated animals with all groups at the indicated time points. Additionally, the results were evaluated using two-way ANOVA to determine the time × drug interaction (please see results in chapter 3.6). V, vehicle.