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. 2019 Sep 26;10:2198. doi: 10.3389/fimmu.2019.02198

Figure 9.

Figure 9

Scheme of drug co-administration (A). Effects of single (B,C) administration of NVP CXCR2 20 (NVP; 10 μg/5 μl; single dose i.t.; on the 7th day post-CCI) (A) on pain-related behaviors (von Frey test A; cold plate test B) and the analgesic effects of morphine (M; 2.5 μg/5 μl; single dose i.t.; on the 7th day post-CCI, 4 h after NVP or V injection) and buprenorphine (B; 2.5 μg/5 μl; single dose i.t.; on the 7th day post-CCI, 4 h after NVP or V injection) on CCI-exposed rats. The data are presented as the means ± SEM of 6 rats per group. Intergroup differences were analyzed using ANOVA with Bonferroni's multiple comparisons test. **p < 0.01, ***p < 0.001 indicate differences compared with naïve rats. #p < 0.05, ##p < 0.01, ###p < 0.001 indicate differences compared V+V-treated, CCI-exposed rats. B, buprenorphine; CCI, chronic constriction injury; M, morphine; N, naive; NVP, NVP CXCR2 20; V, vehicle.