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. 2019 Aug 19;15(10):2240–2255. doi: 10.7150/ijbs.35356

Figure 7.

Figure 7

The exosomes secreted by irradiated HaCaT cells inhibit wound healing in vivo. (A) in vivo tracking of DiI-labelled exosomes (red) in mouse on different days after exosome injection. (B) The representative images of the wounds on both sides of the lower back of the same mouse on different days after subcutaneous injection of the exosomes from unirradiated and irradiated HaCaT cells. (C) The quantification of the size of the wounds on both sides of the lower back of the same mouse on different days after subcutaneous injection of exosomes from unirradiated and irradiated HaCaT cells (n=7). (D) The representative H&E staining images of the epidermis growing back in the wound areas after subcutaneous injection of the exosomes from unirradiated and irradiated HaCaT cells, showing thicker epidermis in wound area subcutaneously injected with exosomes from irradiated HaCaT cells. (E) The quantification of the thickness of epidermis growing back in the wound areas after subcutaneous injection of exosomes from unirradiated and irradiated HaCaT cells. The data represent the means ± SE from 7 mice (n=7). *P<0.05 compared with the relative control. NS, not significant.