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. 2019 Aug 19;15(10):2224–2239. doi: 10.7150/ijbs.35347

Figure 1.

Figure 1

The impact of cld7 on the protein profile of pancreatic cancer cells and TEX. (A) Representative examples of WB and flow-cytometry overlays of cld7 expression in ASML-wt, -cld7kd and -cld7mP cells and TEX. (B-E) NanoLC-ESI-MS/MS proteome analysis of ASML-wt, -cld7kd and -cld7mP cells and TEX. Distinctly recovered proteins were evaluated in (B) cells and (C) TEX for the indicated enrichments according to KEGG; (D,E) Panther/Reactome analysis of cell compartment localization of proteins recovered at a higher level in ASML-wt than -cld7kd and -cld7mP cells and TEX; (D,E) full names of synonyms in Table S6. The strong overrepresentation of transporter and vesicle biogenesis-associated molecules in wt cells and TEX indicates engagement of cld7.