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. 2019 Aug 24;15(11):2330–2339. doi: 10.7150/ijbs.33881

Figure 1.

Figure 1

FZD2 is overexpressed in head and neck squamous cell carcinoma. The differential expression of Frizzled receptors in head and neck squamous cell carcinoma 501 cases of cancer and 41 cases of normal) and tongue cancer (149 cases of cancer and 15 cases of normal) from the TCGA database and the -Log10(P value) by t test was showed (A). The expression of FZD2 in head and neck squamous cell carcinoma and tongue cancer compared with normal tissues (B, N: normal tissues, C: cancer tissues). The overall survival of patients with HNSCC according to the different expression levels of FZD2 based on the TCGA database (C, 194 cases with high and 307 cases with low FZD2 expression, P=0.02 by Mantel-Cox test). Representative images of the upregulation of FZD2 in HNSCC from the Oncomine database (D). The expression of FZD2 in 44 pairs of tongue cancer tissues and adjacent tissues was detected by real-time PCR (E, P<0.05 by t test, n=44).