Skip to main content
. 2019 Sep 7;15(11):2497–2508. doi: 10.7150/ijbs.37481

Figure 1.

Figure 1

HK2 is required for the maintaining of tumorigenic properties in human colorectal cancer cells. A and B, 2-DG uptake (A) and normalized lactate production (B) in colorectal cancer cells and normal colon epithelial cells. The lactate production was normalized to the level of FHC cells. C, immunoblot (IB) analysis of HK2 expression in colorectal cancer cells and normal colon epithelial cells. D, immunohistochemistry (IHC) analysis of HK2 in colorectal cancer tissues and matched adjacent tissues. E, MTS analysis of cell proliferation of HK2 knockout and control HCT116 (left) and SW620 (right) stable cells. F, colony formation of HK2 knockout and control HCT116 (top) and SW620 (bottom) stable cells. G-I, average tumor volume (G), photographed xenograft tumors (H), and average tumor weight (I) of HCT116 sgCtrl and HCT116 sgHK2 xenografts. Data are shown as mean values ± S.D. ***p<0.001, a significant difference between groups as indicated.