Figure 6.

Xanthohumol inhibits tumor growth in colorectal cancer athymic nude mouse model. A and B, tumor volumes of HT29 (A) and HCT116 (B) xenograft tumors treated with xanthohumol or vehicle. C and D, at the treatment endpoint, mice were sacrificed, and HT29 (C) and HCT116 (D) xenograft tumors were removed, weighed, and photographed. E and F, the average body weight of HT29 (E) or HCT116 (F) tumor-bearing mice treated with xanthohumol or vehicle. G. Immunohistochemical examination of Ki67, p-Akt, and HK2 in tumor sections from xanthohumol- or vehicle-treated mice. All panels are of the same magnification. Data are shown as mean values ± S.D. *p<0.05, ***p<0.001, a significant difference between groups as indicated.