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. 2019 Sep 7;15(11):2448–2460. doi: 10.7150/ijbs.37241

Figure 1.

Figure 1

Rictor ablation in BMSCs attenuates formation of breast cancer cell-induced osteolytic lesion in vivo.Representative bone destruction in tibiae detected by X-ray (A) and 3-dimensional (3D) micro-CT in longitudinal tibia sections(B).The red wireframes show the metastatic sites. (C) Measurement of bone volume fraction (Bone volume / Total volume). (D) Representative images of collagen-1 staining in metastatic sites. (E) Quantification of collagen-1-positive area relative to section area. (F) Representative images of total collagen staining in metastatic sites. (G) Quantification of total collagen-positive area relative to section area. Scale bar=50 µm. All bar graphs show mean ± SEM. **P <0.01.