Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Sep 7;15(11):2393–2407. doi: 10.7150/ijbs.35736

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The author(s)

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.

PMC Copyright notice

AMPKa1 knock down abrogates the protective effects of CRAMP. Diabetic mice were subjected to myocardial injection of lenti-shAMPKa1 and treated with CRAMP. A. The expression level of AMPKa1 in heart 0, 1, 2, 4 weeks after injection of lenti-shAMPKa1 (n=6). B. Body weight of mice at 0, 1, 2, 3, 4 months after STZ injection (n=10). D. Blood glucose and body weight of mice at 0, 1, 2, 3, 4 months after STZ injection (n=10). D. Representative image of the heart with Picro-Sirius red (PSR) staining (n=6) and Quantification of the total collagen volume in the indicated group. E. PCR analysis of fibrotic markers (collagen I, collagen III, TGFβ, CTGF) in diabetic heart tissue (n=6). F. Immunofluorescence staining of CD31 and α-SMA in diabetic hearts (n=6). G. PCR analysis of EndMT markers (snial1, snial2, twist1, twist2) in diabetic heart tissue (n=6). *P<0.05 vs the corresponding sham; #P<0.05 vs. vehicle-DCM.

AMPKa1 knock down abrogates the protective effects of CRAMP. Diabetic mice were subjected to myocardial injection of lenti-shAMPKa1 and treated with CRAMP. A. The expression level of AMPKa1 in heart 0, 1, 2, 4 weeks after injection of lenti-shAMPKa1 (n=6). B. Body weight of mice at 0, 1, 2, 3, 4 months after STZ injection (n=10). D. Blood glucose and body weight of mice at 0, 1, 2, 3, 4 months after STZ injection (n=10). D. Representative image of the heart with Picro-Sirius red (PSR) staining (n=6) and Quantification of the total collagen volume in the indicated group. E. PCR analysis of fibrotic markers (collagen I, collagen III, TGFβ, CTGF) in diabetic heart tissue (n=6). F. Immunofluorescence staining of CD31 and α-SMA in diabetic hearts (n=6). G. PCR analysis of EndMT markers (snial1, snial2, twist1, twist2) in diabetic heart tissue (n=6). *P<0.05 vs the corresponding sham; #P<0.05 vs. vehicle-DCM.