Table 3.
Echocardiography and hemodynamics Parameters in diabetic mice after injected with Ad-shAMPKα1 and treated with CRAMP.
| Vehicle-CON (n=8) | CRAMP-CON (n=8) | Vehicle-DCM (n=8) | CRAMP -DCM (n=8) | |
|---|---|---|---|---|
| LVEF (%) | 61.8±3.9 | 62.1±3.6 | 38.6±3.1* | 38.5±4.7* |
| LVFS (%) | 30.6±1.7 | 29.8±3.9 | 14.9±2.5* | 15.4±1.9*# |
| HR (bpm) | 485±46 | 496±50 | 496±69 | 486±53 |
| dp/dt max (mmHg/s) | 8394±481 | 8497±561 | 3745±438* | 3776±439* |
| dp/dt min(mmHg/s) | -8975±766 | -8736±819 | -3851±807* | -3945±629* |
| Tau (Weiss; ms) | 9.28±1.34 | 8.87±1.37 | 22.23±3.19* | 23.13±2.02* |
LVEF, left ventricular ejection fraction; LVFS, left ventricular ejection of shortening; HR, heart rate; dp/dtmax, maximal rate of pressure development; dp/dtmin, maximal rate of pressure decay; Tau, time constant of LV pressure decay *P<0.05 for difference from corresponding sham group. #P<0.05 vs vehicle-DCM group.