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. 2019 Sep 26;10:2271. doi: 10.3389/fimmu.2019.02271

Figure 1.

Figure 1

Ten-Eleven Translocation (TET1, TET2, and TET3) family enzymes are associated with allergic rhinitis (AR) in human patients. (A) Representative gating strategies of flow cytometry analyses for peripheral blood mononuclear cells (PBMCs) and Lin−HLA-DR+CD11c+CD123− myeloid DCs (mDCs) and Lin−HLA-DR+CD11c− CD123+ plasmacytoid DCs (pDCs). (B) Representative histogram plots of TET1, TET2, and TET3 expression in mDCs and pDCs. (C–E) Expression of TET enzymes in PBMCs (C), mDCs (D), and pDCs (E) in healthy controls (HC) and AR patients. The relative median fluorescence intensity (rMFI) was defined as the median fluorescence intensity (MFI) of TET divided by the MFI of Isotype. (F) TET family mRNA expression levels in PBMCs of healthy controls and AR patients. (G,H) Global 5mC (G) and 5hmC (H) levels in PBMCs of healthy controls and AR patients. Values were presented as means ± SEMs. Mann-Whitney tests were conducted. *p < 0.05, ** p < 0.01, and *** p < 0.001.