TABLE 2.
Top 25 IPA-predicted upstream regulators based on RNA-Seq data at 7 and 21 dpia
| Upstream regulator at 7 dpi |
FC at 7 dpi |
P value | Upstream regulator at 21 dpi |
FC at 21 dpi |
P value |
|---|---|---|---|---|---|
| LPS | 8.07E−147 | LPS | 8.52E−58 | ||
| IFN-γ | 7.684 | 4.84E−119 | IL-1β | 3.163 | 3.70E−30 |
| CSF2 | 1.23E−84 | IL-4 | 3.71E−30 | ||
| IL-6 | 4.096 | 2.07E−79 | TNF | 1.46E−29 | |
| STAT3 | 2.032 | 1.81E−74 | Phorbol myristate acetate |
2.58E−29 | |
| STAT1 | 11.417 | 1.48E−68 | IFN-γ | 3.20E−28 | |
| Poly(rI:rC) RNA | 2.98E−68 | IL-2 | 3.08E−26 | ||
| TNF | 2.44E−66 | PPARA | −2.541 | 2.43E−24 | |
| E. coli B4 LPS | 1.72E−65 | IL-10 | 9.74E−24 | ||
| IL-1β | 7.953 | 8.01E−64 | E. coli B5 LPS | 9.94E−24 | |
| IL-10Rα | 6.271 | 2.29E−62 | TGF-β1 | 2.280 | 6.50E−23 |
| IFN-α | 3.30E−62 | IL-10Rα | 2.328 | 7.62E−22 | |
| IL-4 | 1.76E−61 | IL-6 | 8.90E−21 | ||
| TLR4 | 1.10E−57 | IL-12 (complex) | 3.59E−19 | ||
| IRF7 | 9.472 | 3.78E−57 | CSF2 | 5.27E−19 | |
| TLR3 | 2.260 | 4.59E−57 | STAT3 | 1.85E−17 | |
| Dextran sulfate | 1.52E−55 | GATA2 | 8.65E−17 | ||
| IFN-β1 | 3.18E−53 | IL-13 | 1.07E−16 | ||
| IFNAR1 | 5.96E−53 | IL-21 | 3.40E−16 | ||
| IL-10 | 1.33E−52 | CEBPA | 5.23E−16 | ||
| IFNAR | 4.87E−51 | LEP | 7.62E−16 | ||
| TGF-β1 | 2.457 | 1.69E−50 | E. coli B4 LPS | 9.55E−16 | |
| IL-21 | 4.72E−50 | STAT6 | 1.36E−15 | ||
| PTGER4 | 1.12E−48 | GATA3 | 5.807 | 3.52E−09 |
a
Upstream regulators are ranked by P value (IPA). Fold change (FC) values for upstream regulators are from RNA-Seq data.