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. 2019 Sep 26;10:2176. doi: 10.3389/fmicb.2019.02176

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Copyright © 2019 Zhang, Sun, Zhao, Chen, Fan, Jiao, Zhao, Wang, Li, Li and Lin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GLP-1 reduces lipid accumulation in the primary hepatocytes. Hepatocytes were stimulated with 100 nM GLP-1 for 24 h. (A) Oil red O staining (original magnification: ×200, n = 6). (B) TG content in hepatocytes was measured and normalized to the total protein. (C) GLP-1 increased the phosphorylation of AMPK and ACC. Intracellular levels of p-AMPK and p-ACC were analyzed by western blotting. Relative phosphorylation levels were calculated by pAMPK/AMPK and pACC/ACC, which were normalized to control. Significant comparisons were calculated by SAS with a post t-test. Data were presented as mean ± SE (n = 6). ^∗∗p < 0.01 and ^∗∗∗p < 0.001.