Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Sep 26;10:2176. doi: 10.3389/fmicb.2019.02176

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Zhang, Sun, Zhao, Chen, Fan, Jiao, Zhao, Wang, Li, Li and Lin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Liraglutide can mimic the effect of GLP-1 on lipid accumulation in the primary hepatocytes. Hepatocytes were treated with 100 nM liraglutide for 24 h. (A) Oil red O staining (original magnification: ×200, n = 6); (B) TG content in hepatocytes, normalized to the total protein (n = 6); (C) mRNA expression levels of GLP-1R, ACC, FABP4, LPL, PPARG, and SREBP-1c after 24 h treatment of liraglutide (n = 6); (D) The phosphorylation levels of pAMPK and pACC, normalized to control (n = 4); (E) The expression of PPARG and CPT1 (n = 4); (F) Effect of exendin on liraglutide-reduced TG content; (G) Exendin inhibited the phosphorylation of AMPK and ACC, normalized to control. Data were presented as mean ± SE. ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001.