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. 2019 Sep 26;10:2214. doi: 10.3389/fmicb.2019.02214

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Copyright © 2019 Lee, Bacchetti, Milush, Shao, Boritz, Douek, Fromentin, Liegler, Hoh, Deeks, Hecht, Chomont and Palmer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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EIS, intact and defective HIV-DNA p6-RT sequences within HLA-DR+ and HLA-DR– CD4+ memory T-cell subsets derived from a chronic participant. A representative phylogenetic tree of a participant from the CHI group (2026). The inner layer shows a maximum likelihood phylogenetic tree that includes all HIV-DNA p6-RT sequences derived from the HLA-DR+ and HLA-DR– T-cells obtained from participant 2026 during therapy (CHI group). The middle layer shows individual HIV-DNA sequences which are part of an EIS within the HLA-DR+ and HLA-DR– T-cells obtained at three earlier time points (Visits 1–3; 5.1–16.0 years after ART initiation) and last time point (Visit 4; 17.7 years after ART initiation), The outer layer shows defective genetic features for individual viral sequences as shown in the legend.