Table 2.
Comparison of characteristics of patients with different ALBI-GGT scores in entire cohort.
| Variable | ALBI-GGT score 1 | ABLI-GGT score 2 | ABLI-GGT score 3 | P |
|---|---|---|---|---|
| Age, year, median, (range) | 53.7 (23.0-83.0) | 54.6 (25.0-92.0) | 54.1 (21.0-78.0) | 0.634 |
| Gender (female/male), % | 52/221 (19.0/81.0) | 45/286 (13.6/86.4) | 13/97 (11.8/88.2) | 0.096 |
| Cirrhosis (yes/no), % | 185/88 (67.8/32.2) | 248/83 (74.9/25.1) | 101/9 (91.8/8.2) | <0.001 |
| ALT, U/L, median (range) | 47.9 (10.0-915.0) | 40.8 (3.0-332.0) | 36.4 (7.0-252.0) | 0.111 |
| AFP, ng/ml, (≤400/>400), % | 205/68 (75.1/24.9) | 249/82 (75.2/24.8) | 44/66 (40.0/60.0) | 0.004 |
| HBsAg (positive/negative), % | 207/66 (75.8/24.2) | 257/74 (77.6/22.4) | 94/16 (85.5/14.5) | 0.114 |
| GGT (≤50/>50), % | 273/0 (100/0) | 81/250 (24.5/75.5) | 0/110 (0/100) | <0.001 |
| Tumor size, cm, (≤5.0/>5.0), % | 216/57 (79.1/20.9) | 186/145 (56.2/43.8) | 56/54 (50.9/49.1) | <0.001 |
| Tumor number (single/multiple), % | 246/27 (90.1/9.9) | 274/57 (82.8/17.2) | 90/20 (81.8/18.2) | 0.020 |
| Microvascular invasion (yes/no), % | 54/219 (19.8/80.2) | 106/225 (32.0/68.0) | 51/59 (46.4/53.6) | <0.001 |
| Differentiation (poor/moderate/well), % | 50/155/68 (18.3/56.8/24.9) | 79/143/109 (23.9/43.2/32.9) | 37/20/53 (33.6/18.2/48.2) | <0.001 |
| Tumor capsule (yes/no), % | 101/172 (37.0/63.0) | 116/215 (35.0/65.0) | 36/74 (32.7/67.3) | 0.717 |
| ALBI (Ⅰ/Ⅱ), % | 273/0 (100/0) | 250/81 (75.5/24.5) | 0/110 (0/100) | <0.001 |
| Child-Pugh grade (A/B), % | 273/0 (100/0) | 329/2 (99.9/0.1) | 109/1 (99.1/0.9) | 0.359 |
| AJCC stage (Ⅰ/Ⅱ/Ⅲ), % | 214/49/10 (78.4/17.9/3.7) | 211/71/49 (63.7/21.5/14.8) | 54/34/22 (49.1/30.9/20.0) | <0.001 |
| BCLC stage (1/2/3), % | 210/55/8 (76.9/20.1/3.0) | 179/126/26 (54.1/38.1/7.8) | 50/48/12 (45.5/43.6/10.9) | <0.001 |
| CLIP stage (0/1/2/3/4), % | 176/77/13/7/0 (64.5/28.2/4.8/2.5/0) | 182/86/34/23/6 (55.0/26.0/10.3/6.9/1.8) | 39/39/15/15/2 (35.5/35.5/13.6/13.6/1.8) | <0.001 |
ALT, Alanine aminotransferase; AFP, Alkaline phosphatase; HBsAg, Hepatitis B virus surface antigen; GGT, Gamma-glutamyl transpeptidase; ALBI, Albumin-bilirubin; AJCC, American Joint Committee on Cancer, BCLC, Barcelona Clinic Liver Cancer; CLIP, Cancer of the Liver Italian Program.