Table 3.

Univariate and Multivariate analyses of prognostic factors for hepatocellular carcinoma patients in training cohort.

	Overall Survival					Disease-free Survival
			Multivariate analysis				Multivariate analysis
Variable	N=520	Univariate P	HR (95%)	P		Univariate P	HR (95%)	P
Age (≥65/<65)	96/424	0.464	—	NA		0.427	—	NA
Gender (female/Male)	83/437	0.101	—	NA		0.508	—	NA
Cirrhosis (yes/no)	389/131	0.005	1.428 (0.957-2.132)	0.081		0.001	1.551 (1.111-2.165)	0.010
HBsAg (positive/negative)	405/115	0.783	—	NA		0.242	—	NA
ALT, U/L, median, (range)	42.6 (3.0-615.0)	0.338	—	NA		0.988	—	NA
AFP, ng/ml, (≤400/>400)	382/138	0.038	0.972 (0.705-1.341)	0.863		0.204	—	NA
Tumor size, cm, (≤5.0/>5.0)	337/183	<0.001	1.980 (1.456-2.694)	<0.001		<0.001	1.633 (1.253-2.130)	<0.001
Tumor number (single/multiple)	446/74	0.002	1.341 (0.924-1.946)	0.123		<0.001	1.489 (1.085-2.045)	0.014
Microvascular invasion (yes/no)	159/361	<0.001	1.972 (1.451-2.679)	<0.001		<0.001	1.601 (1.227-2.091)	0.001
Differentiation	173/226/121
well		0.012
moderate		0.001	1.153 (0.849-1.564)	0.182		0.031	1.162 (0.895-1.510)	0.314
poor		0.004	1.382 (0.721-1.621)	0.091		0.001	1.195 (0.826-1.531)	0.121
Tumor capsule (yes/no)	194/326	0.597	—	NA		0.062	—	NA
Child-Pugh grade (A/B)	518/2	0.044	1.173 (0.866-1.589)	0.302		0.057	—	NA
ALBI-GGT	205/233/82
ALBI-GGT (1)		<0.001				<0.001
ALBI-GGT (2)		<0.001	1.663 (1.146-2.413)	0.007		<0.001	1.503 (1.110-2.034)	0.008
ALBI-GGT (3)		<0.001	1.947 (1.242-3.052)	0.004		<0.001	1.638 (1.119-2.398)	0.011

ALT, Alanine aminotransferase; AFP, Alkaline phosphatase; HBsAg, Hepatitis B virus surface antigen; GGT, Gamma-glutamyl transpeptidase; ALBI, Albumin-bilirubin.