Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Aug 27;10(20):4913–4920. doi: 10.7150/jca.32582

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The author(s)

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.

PMC Copyright notice

Fig 4 — L-dopa treatment. (A) An MTS assay shows a significant decrease in cellular viability above L-dopa concentrations of 200 µM in a concentration-dependent manner (N=3). (B, C) L-dopa concentrations above 50 µM inhibit SYT12 mRNA and protein expression levels in the L-dopa-treated cells compared with controls (N=3). (D) The cellular growth of the L-dopa-treated cells is significantly (P < 0.05) lower than that of the control cells after 7 days (168 h) (N=3). (E) A flow cytometric analysis shows the percentage of L-dopa-treated cells in the G1 phase is increased compared with the control cells (N=3). (F) Immunoblot analysis shows up-regulation of p27^Kip1 and down-regulation of CDK2 and cyclin E in the L-dopa-treated cells compared with the control cells (N=3).