Table 3.
Association of the 2 SNPs in MAGE-A11 gene and risk of RCC in totality and validation set.
| Stages | SNPs | OR (95% CI)a | Pb | Bonferronic | ||||
|---|---|---|---|---|---|---|---|---|
| Additive model | Dominant model | Recessive model | Codominant model | |||||
| het | hom | |||||||
| Totality | rs6641352 | 1.250 (1.069-1.461) | 1.315 (1.089-1.588) | 1.299 (0.855-1.975) | 1.299 (1.066-1.583) | 1.423 (0.931-2.174) | 0.005 | 0.020 |
| rs6540341 | 1.275 (1.102-1.476) | 1.301 (1.081-1.564) | 1.614 (1.123-2.320) | 1.226 (1.009-1.491) | 1.740 (1.202-2.519) | 0.001 | 0.004 | |
| Validation | rs6641352 | 1.309 (1.049-1.633) | 1.456 (1.113-1.905) | 1.112 (0.618-2.001) | 1.489 (1.123-1.974) | 1.269 (0.700-2.302) | 0.017 | 0.068 |
| rs6540341 | 1.298 (1.056-1.596) | 1.317 (1.014-1.711) | 1.717 (1.030-2.862) | 1.228 (0.931-1.619) | 1.852 (1.100-3.120) | 0.013 | 0.052 | |
Values in bold indicate are statistically different.
aLogistic regression model with adjustment for age, sex, BMI, smoking status, drinking status, hypertension, diabetes and family history of cancer in additive (rare homozygote versus heterozygote versus major homozygote) models, dominant (heterozygote/rare homozygote versus major homozygote), recessive (rare homozygote versus heterozygote/major homozygote) and codominant (het: heterozygote versus major homozygote; hom: rare homozygote versus major homozygote). BMI, body mass index; OR, odds ratio.
bAdjusted for age, sex, BMI, smoking status, drinking status, hypertension, diabetes and family history of cancer in additive model
cBonferroni correction for additive model.