Table 4.
Associations between the 2 SNPs in MAGE-A11 gene and RCC patients' survival.
| rs6641352 (T/C) | Patients/deaths | 5-year survival (%)a | Log-rank P | Crude HR (95% CI) | HR (95% CI)b | Pb |
|---|---|---|---|---|---|---|
| Total number of subjects | 308/32 | 80 | ||||
| Codominant model | ||||||
| TT | 191/17 | 81 | 1.000 (reference) | 1.000 (reference) | ||
| TC | 104/9 | 86 | 0.554 | 0.803 (0.353-1.823) | 0.753 (0.291-1.953) | 0.560 |
| CC | 13/6 | —— | 0.001 | 4.193 (1.635-10.757) | 3.217 (0.940-11.013) | 0.063 |
| P trend | 0.079 | |||||
| Additive model | 0.001 | 1.625 (0.940-2.809) | 1.415 (0.773-2.592) | 0.261 | ||
| Dominant model | ||||||
| TT | 191/17 | 81 | 1.000 (reference) | 1.000 (reference) | ||
| TC/CC | 117/15 | 79 | 0.653 | 0.636 (0.584-2.410) | 1.110 (0.488-2.523) | 0.804 |
| Recessive model | ||||||
| TT/TC | 295/26 | 83 | 1.000 (reference) | 1.000 (reference) | ||
| CC | 13/6 | —— | <0.001 | 4.569 (1.870-11.161) | 3.526 (1.072-11.595) | 0.038 |
BMI, body mass index; HR, hazard ratio.
Values in bold indicate statistically different.
aProportion of survival derived from Kaplan-Meier analysis.
bAdjusted for age, sex, BMI, smoking status, drinking status, hypertension, diabetes and family history of cancer, clinical stage, tumor stage and histology in Cox regression model.