Table 1.
Inhibitory effect of Fucoidan-Sargassum on HCC and normal liver cell lines
| Inhibition rate of Fucoidan-Sargassum in dose increments | |||||
|---|---|---|---|---|---|
| Time | Cell line | 5mg/mL | 10mg/mL | 20mg/mL | 30mg/mL |
| h | % | % | % | % | |
| 24 | HL-7702† | 2.8 | 2.4 | 2.1 | ___ |
| Huh7 | 0.3‡ | 9.3* | 23.2*** | ___ | |
| SMMC-7721 | ___ ‡ | 6.4 | 17.6** | 28.4*** | |
| HCCLM3 | ___ | 12.9* | 24.1*** | 24.9*** | |
| 48 | HL-7702† | 2.8 | 4.1 | 6.9* | ___ |
| Huh7 | 7.3* | 21.7*** | 40.2**** | ___ | |
| SMMC-7721 | ___ | 8.2 | 17.8** | 28.2*** | |
| HCCLM3 | ___ | 13.4** | 27.9*** | 43.8**** | |
| 72 | HL-7702† | 3.1 | 4.8 | 6.4* | ___ |
| Huh7 | 4.5 | 32.2*** | 48.8**** | ___ | |
| SMMC-7721 | ___ | 7.8* | 29.2*** | 46.9**** | |
| HCCLM3 | ___ | 12.1** | 35.7**** | 51.3**** | |
Data are inhibition rates of 3 dose increments for 4 cell lines. †Normal liver cell line. ‡Not determined. *P < .05, ** P < .01, *** P < .001, **** P < .0001 vs. control, by two-way ANOVA.