Table 4.
Results of mixed-effects linear regression of the clinical outcome ‘protease activity’ as a function of time, mean gingival inflammation over time and mean gingival inflammation at day − 14
| Explanatory variables | Protease activity | |||||
|---|---|---|---|---|---|---|
| Total sample (n = 18) | ‘Fast’ responders (n = 7) | ‘Slow’ responders (n = 11) | ||||
| Coefficient (95% CI) | p value | Coefficient (95% CI) | p value | Coefficient (95% CI) | p value | |
| Time (days) (reference: day 0) | < 0.001 | 0.017 | 0.020 | |||
| + 7 | 0.52 (0.14–1.17) | 1.40 (0.04–2.70) | 0.53 (0.00–1.05) | |||
| + 14 | 1.03 (0.41–2.48) | 2.21 (0.28–4.14) | 0.92 (0.04–0.21) | |||
| + 21 | 2.33 (0.54–4.12) | 3.50 (1.44–5.54) | 1.02 (0.09–1.95) | |||
| + 35 | 1.35 (0.85–1.87) | 1.04 (0.33–1.75) | 1.00 (0.46–1.54) | |||
| Gingival inflammation | − 0.33 (1.11–0.45) | 0.391 | − 0.73 (− 1.23 to − 0.25) | 0.031 | − 0.10 (− 0.41 to 0.21) | 0.443 |
| Gingival inflammation (day − 14) | − 0.05 (0.25–0.16) | 0.824 | 0.04 (− 0.20–0.30) | 0.662 | 0.01 (− 0.33 to 0.35) | 0.762 |
The coefficient denotes the mean difference of the protease activity outcome given the explanatory variables included in the model. The analysis was adjusted by protein level. Values in bold indicate statistical significance compared to baseline (p < 0.05)
CI confidence interval