Figure 1.

Memory retention in 18 mo. knock out (NC) and h-Tau carrier (C) mice after treatment with TA. Mice (N= 7/group) were tested on functions of learning and memory as stated in the “Behavioral studies” section. (a) and (b) average latency in seconds and the swimming velocity in m/s during the seven days of acquisition training, (c) represents average distance swam, in centimeters, during the seven days of acquisition training. Each data point is representative of the average latency, velocity, or distance swam per day. Values are expressed as mean ± standard error of the mean. P < 0.05 considered significant by ANOVA, noted by “*” (C-CTRL versus C-TA) and “+” (NC-TA versus C-TA). Significance was only seen during average distance travelled and (d) to (f) memory retention, average distance, and swimming velocity were assessed by a 60 s probe trial on day 8 (Probe trial 1), following the last day of acquisition testing. Probe trial was repeated after day 18 (Probe trial 2), to create a 10-day latency period. Bar diagram represents the average total time, in seconds, spent by mice in the PFZ, average distance (in cm) and average velocity (in m/s). Values are expressed as mean ± standard error of the mean. No significance was observed.

NC: non-carriers for tau; TA: tolfenamic acid.