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Plasma and brain exposure of MTf and MTfpep targeted IgG-IL-1RA fusion molecules in a mouse PK assay. (a) Plasma PK of MTf and MTfpep targeted hIgG fused to IL-1RA compared to a non-targeted isotype control (NIP228) over a two-week period. (b) Brain exposure as a measure of % injected dose per gram of brain. All molecules dosed at the same molar concentration. N = 6 per group. PK: pharmacokinetic; IL-1RA: interleukin 1 receptor antagonist.
