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. 2018 May 30;39(10):2074–2088. doi: 10.1177/0271678X18772998

Figure 6.

Figure 6.

The analgesic effect of MTf-IL-1RA fusions on the mouse partial nerve ligation model. (a) Comparison of the analgesic effect of IL-1RA fusion constructs containing MTf and MTfpep with isotype control (NIP228), vehicle control and non-ligated (sham operated) control group. N = 8 per group. Data analysed using two-way ANOVA with time and treatment as dependant factors. Subsequent statistical significance obtained using Tukey's POST HOC test. ++ P<0.01; +++ P<0.001 – Op + NIP228-IL-1RA vs. Op + MTf-Fc-IL-1RA 135 mg/kg; *** P < 0.001 – Op + NIP228-IL-1RA vs. Op + MTfpep-NH-NIP228-IL-1RA 100 mg/kg; @@@P < 0.001 – Op + NIP228 vs. Op + MTfpep-ADC-NIP228-IL-1RA 100 mg/kg. (b) Dose response of MTfpep targeted NIP228 hIgG1TM-IL-1RA fusions on the reversal of partial nerve ligation-induced mechanical hyperalgesia. N = 7–10 per group. Data analysed using two-way ANOVA with time and treatment as dependent factors. Subsequent statistical significance obtained using Tukey’s post hoc test. *P < 0.05; ** P < 0.01 – NIP228 vs. MTfpep 50 mg/kg; +++ P < 0.001 – NIP228 vs. MTfpep 100 mg/kg.