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. 2019 Sep 26;10:1131. doi: 10.3389/fphar.2019.01131

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Copyright © 2019 Ceprián, Vargas, García-Toscano, Penna, Jiménez-Sánchez, Achicallende, Elezgarai, Grandes, Hind, Pazos and Martínez-Orgado

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Myelin study in white matter by electron microscopy. Electron microscopy studies performed in the external capsula of the corpus callosum 30 days after a hypoxic-ischemic (HI) insult induced in P7–10 Wistar rats then receiving vehicle (HV) or cannabidiol (HC), or a similar period in control rats (SHM). (A) Number of axons (B) myelin sheath thickness (C) Axon perimeter (D) g-ratio (E) Dots and trend lines representing the relationship between axon size and g-ratio values (F) Representative micrographs. Bars represent mean ± SEM. Scale bar: 10 µm. *p < 0.05 vs SHM; ^#p < 0.05 vs HV, by ANOVA.