Table 1.
Overall survival analysis of HLA family genes
| Variables | Overall survival | ||||||
|---|---|---|---|---|---|---|---|
| Patients (n=212) | No. of event | MST (month) | HR (95%CI) | Crude P value | HR (95%CI) | Adjusted P valueɸ | |
| HLA-A | |||||||
| Low expression | 106 | 43 | NA | Ref. | Ref. | ||
| High expression | 106 | 39 | NA | 0.824 (0.534-1.271) | 0.382 | 0.730 (0.468-1.139) | 0.166 |
| HLA-B | |||||||
| Low expression | 106 | 43 | NA | Ref. | Ref. | ||
| High expression | 106 | 39 | NA | 0.921 (0.597-1.421) | 0.711 | 1.016 (0.657-1.573) | 0.942 |
| HLA-C | |||||||
| Low expression | 106 | 45 | NA | Ref. | Ref. | ||
| High expression | 106 | 37 | NA | 0.770 (0.498-1.190) | 0.239 | 0.736 (0.474-1.141) | 0.170 |
| HLA-DMA | |||||||
| Low expression | 106 | 44 | NA | Ref. | Ref. | ||
| High expression | 106 | 38 | NA | 0.809 (0.524-1.249) | 0.339 | 0.785 (0.508-1.215) | 0.278 |
| HLA-DMB | |||||||
| Low expression | 106 | 38 | NA | Ref. | Ref. | ||
| High expression | 106 | 44 | NA | 1.204 (0.780-1.859) | 0.401 | 1.173 (0.745-1.845) | 0.491 |
| HLA-DOA | |||||||
| Low expression | 106 | 43 | NA | Ref. | Ref. | ||
| High expression | 106 | 39 | NA | 0.923 (0.598-1.423) | 0.716 | 0.997 (0.636-1.562) | 0.988 |
| HLA-DOB | |||||||
| Low expression | 106 | 37 | NA | Ref. | Ref. | ||
| High expression | 106 | 45 | NA | 1.295 (0.838-2.001) | 0.245 | 1.304 (0.837-2.030) | 0.241 |
| HLA-DPA1 | |||||||
| Low expression | 106 | 38 | NA | Ref. | Ref. | ||
| High expression | 106 | 44 | NA | 1.110 (0.719-1.713) | 0.638 | 1.198 (0.766-1.874) | 0.429 |
| HLA-DPB1 | |||||||
| Low expression | 106 | 35 | NA | Ref. | Ref. | ||
| High expression | 106 | 47 | 60.50 | 1.587 (1.024-2.460) | 0.039 | 1.566 (0.998-2.458) | 0.051 |
| HLA-DQA1 | |||||||
| Low expression | 106 | 44 | NA | Ref. | Ref. | ||
| High expression | 106 | 38 | NA | 0.846 (0.548-1.306) | 0.449 | 0.563 (0.359-0.883) | 0.012 |
| HLA-DQB1 | |||||||
| Low expression | 106 | 38 | NA | Ref. | Ref. | ||
| High expression | 106 | 44 | NA | 1.222 (0.792-1.888) | 0.365 | 1.393 (0.896-2.166) | 0.141 |
| HLA-DQB2 | |||||||
| Low expression | 106 | 40 | NA | Ref. | Ref. | ||
| High expression | 106 | 42 | NA | 1.012 (0.656-1.560) | 0.957 | 0.968 (0.624-1.501) | 0.884 |
| HLA-DRA | |||||||
| Low expression | 106 | 42 | NA | Ref. | Ref. | ||
| High expression | 106 | 40 | NA | 0.920 (0.596-1.418) | 0.705 | 0.816 (0.523-1.272) | 0.369 |
| HLA-DRB1 | |||||||
| Low expression | 106 | 42 | NA | Ref. | Ref. | ||
| High expression | 106 | 40 | NA | 0.927 (0.601-1.430) | 0.732 | 0.742 (0.468-1.177) | 0.205 |
| HLA-DRB4 | |||||||
| Low expression | 106 | 44 | NA | Ref. | Ref. | ||
| High expression | 106 | 38 | NA | 0.905 (0.586-1.398) | 0.654 | 0.869 (0.562-1.345) | 0.529 |
| HLA-DRB6 | |||||||
| Low expression | 106 | 46 | NA | Ref. | Ref. | ||
| High expression | 106 | 36 | NA | 0.738 (0.477-1.142) | 0.173 | 0.893 (0.569-1.402) | 0.624 |
| HLA-E | |||||||
| Low expression | 106 | 42 | NA | Ref. | Ref. | ||
| High expression | 106 | 40 | NA | 0.909 (0.589-1.402) | 0.666 | 1.102 (0.691-1.755) | 0.684 |
| HLA-F | |||||||
| Low expression | 106 | 46 | NA | Ref. | Ref. | ||
| High expression | 106 | 36 | NA | 0.636 (0.411-0.985) | 0.043 | 0.576 (0.371-0.896) | 0.014 |
| HLA-G | |||||||
| Low expression | 106 | 40 | NA | Ref. | Ref. | ||
| High expression | 106 | 42 | NA | 1.128 (0.731-1.739) | 0.586 | 1.289 (0.830-2.003) | 0.258 |
Note: ɸ: P values were adjusted for tumor size, cirrhosis, AFP and BCLC stage.