Table 2.

Recurrence-free survival analysis of HLA family genes

Variables		Recurrence-free survival
	Patients (n=212)	No. of event	MST (month)	HR (95%CI)	Crude P value	HR (95%CI)	Adjusted P valueѰ
HLA-A
Low expression	106	61	35.20	Ref.		Ref.
High expression	106	55	51.60	0.780 (0.542-1.123)	0.182	0.638 (0.439-0.930)	0.019
HLA-B
Low expression	106	58	43.20	Ref.		Ref.
High expression	106	58	45.90	0.989 (0.687-1.424)	0.954	1.105 (0.764-1.598)	0.597
HLA-C
Low expression	106	67	30.7	Ref.		Ref.
High expression	106	49	57.9	0.649 (0.448-0.938)	0.022	0.664 (0.458-0.963)	0.031
HLA-DMA
Low expression	106	61	40.4	Ref.		Ref.
High expression	106	55	49.1	0.894 (0.621-1.287)	0.545	0.923 (0.640-1.332)	0.669
HLA-DMB
Low expression	106	52	53.0	Ref.		Ref.
High expression	106	64	29.9	1.387 (0.962-2.001)	0.080	1.378 (0.943-2.015)	0.098
HLA-DOA
Low expression	106	60	36.0	Ref.		Ref.
High expression	106	56	51.1	0.906 (0.629-1.305)	0.596	0.894 (0.617-1.294)	0.553
HLA-DOB
Low expression	106	56	51.1	Ref.		Ref.
High expression	106	60	37.9	1.179 (0.819-1.697)	0.376	1.116 (0.772-1.615)	0.559
HLA-DPA1
Low expression	106	63	36.6	Ref.		Ref.
High expression	106	53	53.3	0.795 (0.552-1.146)	0.219	0.673 (0.462-0.982)	0.040
HLA-DPB1
Low expression	106	57	49.1	Ref.		Ref.
High expression	106	59	30.9	1.236 (0.858-1.779)	0.255	1.257 (0.860-1.837)	0.237
HLA-DQA1
Low expression	106	61	40.4	Ref.		Ref.
High expression	106	55	53.3	0.887 (0.616-1.277)	0.518	0.658 (0.451-0.960)	0.030
HLA-DQB1
Low expression	106	61	46.3	Ref.		Ref.
High expression	106	55	40.4	0.948 (0.658-1.365)	0.772	1.009 (0.699-1.458)	0.960
HLA-DQB2
Low expression	106	55	46.3	Ref.		Ref.
High expression	106	61	37.9	1.164 (0.809-1.676)	0.413	1.202 (0.833-1.735)	0.324
HLA-DRA
Low expression	106	60	37.9	Ref.		Ref.
High expression	106	56	51.1	0.851 (0.591-1.226)	0.386	0.786 (0.541-1.141)	0.206
HLA-DRB1
Low expression	106	57	46.3	Ref.		Ref.
High expression	106	59	41.6	1.000 (0.695-1.440)	0.998	0.937 (0.635-1.380)	0.740
HLA-DRB4
Low expression	106	58	32.7	Ref.		Ref.
High expression	106	58	49.1	0.992 (0.689-1.429)	0.967	0.952 (0.659-1.374)	0.793
HLA-DRB6
Low expression	106	59	43.2	Ref.		Ref.
High expression	106	57	46.1	0.943 (0.655-1.357)	0.753	1.006 (0.696-1.453)	0.975
HLA-E
Low expression	106	57	41.6	Ref.		Ref.
High expression	106	59	46.1	0.999 (0.694-1.439)	0.997	1.087 (0.745-1.585)	0.667
HLA-F
Low expression	106	62	28.7	Ref.		Ref.
High expression	106	54	53.0	0.736 (0.511-1.061)	0.100	0.706 (0.488-1.021)	0.064
HLA-G
Low expression	106	60	37.9	Ref.		Ref.
High expression	106	56	46.3	0.933 (0.648-1.343)	0.708	1.042 (0.717-1.514)	0.831

Note: Ѱ: P values were adjusted for gender, cirrhosis and BCLC stage.