Table 3.

Univariate and multivariate analyses of the factors influencing OS by Cox proportional hazard model

	Univariate analysis		Multivariate analysis
	HR (95% CI)	P value	HR (95% CI)	P value
Age (year)
≤60 vs. >60	1.374 (0.923-2.048)	0.118
Gender
Female vs. Male	1.224 (0.799-1.876)	0.353
Primary tumor site
Colon vs. Rectum	1.837 (1.235-2.732)	0.003	2.174 (1.448-3.364)	<0.001
T stage
1-3 vs. 4	1.096 (0.746-1.611)	0.639
N stage
0 vs. 1-2	1.955 (1.271-3.005)	0.002	2.414 (1.552-3.754)	<0.001
Histological
Well/moderate vs. Poor	1.472 (0.861-2.518)	0.157
Liver metastases tumor size (cm)
≤2.3 vs. >2.3	1.476 (0.987-2.207)	0.058
Liver metastases number
Single vs. Multiple	1.685 (1.128-2.518)	0.011	2.027 (1.343-3.058)	0.001
Hepatic resection timing
Synchronous vs. Metachronous	1.297 (0.871-1.930)	0.200
CEA (ng/ml)
≤5 vs. >5	1.245 (0.829-1.870)	0.290
CA199 (U/ml)
≤37 vs. >37	1.051 (0.659-1.678)	0.834
AFU (U/L)
≤30.8 vs. >30.8	0.601 (0.367-0.984)	0.043	0.438 (0.264-0.728)	0.001

Abbreviations: OS, overall survival; HR, hazard ratio; CI, confidence interval; CEA, carcinoembryonic antigen; CA19-9, cancer antigen 19-9; AFU, alpha-l-fucosidase.