TABLE I.
Characteristics of Prader-Willi Syndrome and Control Subjects
| Subject groupa | Sex M/F | N | Age (year) X ± SEM | BMI (kg/m2) X ± SEM | Leptin (ng/ml) X ± SEM |
|---|---|---|---|---|---|
| PWS obeseb | M | 13 | 18.9 ± 3.4 | 36.9 ± 2.9 | 32.5 ± 8.7 |
| PWS obese | F | 6 | 20.4 ± 3.4 | 37.5 ± 1.8 | 34.3 ± 6.9 |
| PWS non-obese | M | 6 | 15.3 ± 3.7 | 22.7 ± 1.4 | 25.2 ± 6.6 |
| PWS non-obese | F | 8 | 10.2 ± 2.9 | 21.3 ± 1.6 | 22.1 ± 5.6 |
| Obese controls | M | 9 | 20.1 ± 4.0 | 34.0 ± 1.9 | 26.0 ± 7.4 |
| Obese controls | F | 19 | 22.8 ± 2.1 | 37.0 ± 2.5 | 46.4 ± 6.3 |
| Non-obese controls | M | 8 | 19.0 ± 4.8 | 20.8 ± 1.7 | 5.4 ± 2.7 |
| Non-obese controls | F | 8 | 23.9 ± 3.4 | 22.5 ± 1.4 | 14.4 ± 4.5 |
a
Obese, BMI > or = 27; non-obese, BMI < 27.
b
Eighteen Prader-Willi syndrome (PWS) patients with 15q11q13 deletion; 13 with normal chromosomes or maternal disomy 15; two with chromosome 15 translocations.