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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Food Chem Toxicol. 2019 Aug 29;133:110793. doi: 10.1016/j.fct.2019.110793

Table 2.

Food consumption by male Wistar rats treated with E 171

A. 7-day Study
Food Consumption
Mean ± S.E.a

Group Treatment g/animal/day g/kg BW/day
1 0 ppm E 171 21.4 ± 0.6 75.8 ± 1.8
2 40 ppm E 171 22.1 ± 0.4 78.9 ± 2.0
3 400 ppm E 171 22.3 ± 0.5 81.6 ± 3.0
4 5000 ppm E 171 23.0 ± 0.3 83.8 ± 1.8b
B. 100-day Study
Food Consumption
Mean ± S.E.a
Week 2 Week 5 Week 10 Week 15

Group Treatment g/animal/day g/kg BW/day g/animal/day g/kg BW/day g/animal/day g/kg BW/day g/animal/day g/kg BW/day
1 0 ppm E 171 23.9 ± 1.4 86.5 ± 5.2 22.8 ± 0.6 64.7 ± 1.7 22.4 ± 0.6 53.8 ± 1.4 22.0 ± 0.5 49.5 ± 1.2
2 40 ppm E 171 22.9 ± 0.4 85.3 ± 1.6 22.7 ± 0.2 66.7 ± 0.7 21.3 ± 0.4 52.2 ± 0.9 21.4 ± 0.3 48.7 ± 0.8
3 400 ppm E 171 23.1 ± 0.5 83.1 ± 1.8 24.8 ± 0.6b 69.8 ± 1.6b 22.6 ± 0.6 52.9 ± 1.4 22.1 ± 0.8 48.7 ± 1.7
4 5000 ppm E 171 23.3 ± 0.2 84.9 ± 0.8 24.7 ± 0.3b 70.9 ± 0.8b 22.7 ± 0.4 54.7 ± 1.1 22.3 ± 0.4 49.9 ± 0.9
5 180 mg/kg DMH · 2HCl 22.3 ± 0.3 85.5 ± 1.2 22.0 ± 0.4 66.5 ± 1.2 21.5 ± 0.3 54.6 ± 0.9 21.4 ± 0.3 50.6 ± 0.7
6 180 mg/kg DMH · 2HCl + 40 ppm E 171 23.4 ± 0.5 89.1 ± 1.7 23.2 ± 0.5 68.8 ± 1.6 22.6 ± 0.5 55.5 ± 1.3 21.7 ± 0.5 49.7 ± 1.2
7 180 mg/kg DMH · 2HCl + 400 ppm E 171 22.1 ± 0.5 85.8 ± 1.9 22.3 ± 0.4c 67.4 ± 1.3 21.5 ± 0.3 53.9 ± 0.9 21.0 ± 0.3 47.6 ± 0.7
8 180 mg/kg DMH · 2HCl + 5000 ppm E 171 23.5 ± 0.8 89.6 ± 3.2 24.0 ± 0.8d 71.6 ± 2.3 22.2 ± 0.8 54.7 ± 1.8 22.2 ± 0.8 51.0 ± 1.8
a

N=10 for all groups

b

Significantly different compared to 0 ppm E 171 group p<0.05

a

N=8 for all groups and all time points

b

Significantly different compared to 0 ppm E 171 group, p<0.05

c

Significantly different compared to 400 ppm E 171 group, p<0.05

d

Significantly different compared to 180 mg/kg DMH · 2HCl group, p<0.05