Table 3.

Water consumption by male Wistar rats treated with E 171

A. 7-day Study
		Water Consumption Mean ± S.E.a
Group	Treatment	g/animal/day	g/kg BW/day
1	0 ppm E171	68.1 ± 1.3	241.1 ± 4.7
2	40 ppm E 171	66.3 ± 1.7	235.9 ± 5.6
3	400 ppm E 171	68.9 ± 1.3	252.9 ± 8.3
4	5000 ppm E 171	69.4 ± 1.4	253.3 ± 6.6

B. 100-day Study
		Water Consumption Mean ± S.E.a
		Week 3		Week 8		Week 13
Group	Treatment	g/animal/day	g/kg BW/day	g/animal/day	g/kg BW/day	g/animal/day	g/kg BW/day
1	0 ppm E 171	37.3 ± 1.6	122.1 ± 5.1	35.6 ± 1.0	90.0 ± 2.6	31.2 ± 1.3	71.5 ± 3.0
2	40 ppm E 171	37.9 ± 3.2	127.4 ± 10.8	34.8 ± 1.6	90.0 ± 4.2	35.2 ± 2.7	81.8 ± 6.3
3	400 ppm E 171	34.9 ± 1.0	113.2 ± 3.3	37.9 ± 2.0	94.1 ± 5.0	32.1 ± 1.1	71.8 ± 2.5
4	5000 ppm E 171	38.8 ± 1.4	128.2 ± 4.6	35.9 ± 2.1	91.9 ± 5.4	33.2 ± 1.8	75.8 ± 4.1
5	180 mg/kg DMH · 2HCl	37.1 ± 1.4	128.5 ± 4.7	35.5 ± 1.3	95.4 ± 3.4	31.8 ± 1.2	76.5 ± 2.9
6	180 mg/kg DMH · 2HCl + 40 ppm E 171	35.6 ± 1.6	121.3 ± 5.5	35.1 ± 2.1	91.3 ± 5.3	32.7 ± 2.1	76.6 ± 4.9
7	180 mg/kg DMH · 2HCl + 400 ppm E 171	37.0 ± 1.6	129.1 ± 5.5b	35.6 ± 1.3	94.9 ± 3.4	32.0 ± 1.8	76.3 ± 4.4
8	180 mg/kg DMH · 2HCl + 5000 ppm E 171	36.5 ± 1.8	124.2 ± 6.2	37.7 ± 2.5	98.3 ± 6.4	32.6 ± 2.3	76.5 ± 5.3

^aN=7 for groups 2 and 8, Week 3. For all other groups and all other time points, N=8.

^bSignificantly different compared to 400 ppm E 171 group, p<0.05