Table 7.

Evaluation of colonic goblet cells in male Wistar rats treated with E 171 for 100 days with or without pretreatment with DMH · 2HCl

Group	Treatment	Mean Length of Gland (units)a,b	Mean No. of Goblet Cells/Unitb
1	0 ppm E 171	4.6 ± 0.1	6.5 ± 0.5
2	40 ppm E 171	5.2 ± 0.2	5.9 ± 0.2
3	400 ppm E 171	4.9 ± 0.3	6.4 ± 0.3
4	5000 ppm E 171	5.3 ± 0.2	6.2 ± 0.3
5	180 mg/kg DMH · 2HCl	5.5 ± 0.3c	6.2 ± 0.4
6	180 mg/kg DMH · 2HCl + 40 ppm E 171	5.0 ± 0.2	5.9 ± 0.4
7	180 mg/kg DMH · 2HCl + 400 ppm E 171	5.3 ± 0.3	6.0 ± 0.4
8	180 mg/kg DMH · 2HCl + 5000 ppm E 171	5.5 ± 0.2	6.2 ± 0.2

^aThe length of the gland from the epithelial luminal surface to the base of the crypt was measured using an ocular micrometer.

^bResults expressed as mean ± S.E. N=5 for all groups except 3 and 8. Only 4 animals in these groups met the criteria for inclusion in goblet cell evaluation

^cSignificantly different compared to 0 ppm E 171 group, p<0.05