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. 2019 Oct 2;39:54. doi: 10.1186/s40880-019-0401-9

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Association between PGK1 promoter hypomethylation and PGK1 mRNA level elevation in multiple cancer types. a All 11 methylation probes have unanimous values in five types of cancer, and these values are higher in normal tissues than in tumor tissues. M value the methylation level, diff difference, T − N, the methylation levels of probes in tumor tissues minus that in normal tissues. b PGK1 promoter methylation is significantly associated with PGK1 mRNA levels in STAD, BLCA, ESCA, LIHC, and BRCA (*P < 0.05, **P < 0.01, independent variable t test). All statistical tests were two-sided. BRCA breast carcinoma, LIHC liver hepatocellular carcinoma, ESCA esophageal carcinoma, BLCA bladder urothelial carcinoma, STAD stomach adenocarcinoma