Fig. 5.

Expression levels of miRNAs in the miR-17-92 and miR-106b-25 clusters according to histologic grade. a Scatterplots show the expression of miRNAs in breast cancer cases according to their histologic grade: grade 1 (G1), grade 2 (G2) or grade 3 (G3). Means and standard deviations from microarray analyses are presented. p-values for comparisons are presented in b. b MiRNA expression in breast cancer cases and in benign tissue controls is presented with microarray expression levels given as mean (standard deviation) of log2 transformed Hy3 intensity values. *False discovery rate (FDR) adjusted p-value < 0.05, **p-value < 0.01. c MiRNA expression in breast cancers and in benign tissue analyzed by qPCR. Expression levels are presented as mean (standard deviation) of normalized PCR quantification cycle (Cq) values based on the average of the normalizer assay detected in all samples and the formula: normalized Cq = average Cq (all samples) − assay Cq (sample). Negative PCR expression values indicate lower expression levels compared to the normalizer. *False discovery rate (FDR) adjusted p-value < 0.05, **p-value < 0.01