Table 2.
Diagnostic performance of independent or combinations of biomarkers
| AUC (95% CI) | Sensitivity (%) | Specificity (%) | Cutoff value | |
|---|---|---|---|---|
| S100A9 | 0.836(0.799-0.869) | 65.9 | 89.1 | 18.22 |
| TNC | 0.768(0.727-0.806) | 57 | 90.1 | 3.87 |
| CEA | 0.736(0.693-0.776) | 44.2 | 92.6 | 3.36 |
| CA199 | 0.655(0.610-0.699) | 57.8 | 68.3 | 10.63 |
| S100A9+TNC | 0.893(0.861-0.920) | 77.13 | 90.59 | _ |
| CEA+CA199 | 0.751(0.709-0.790) | 57 | 80.2 | _ |
| TNC+CEA+CA199 | 0.841(0.804-0.873) | 77.5 | 81.2 | _ |
| S100A9+TNC+CEA | 0.908(0.878-0.933) | 79.8 | 89.6 | _ |
| S100A9+TNC+CA19-9 | 0.898(0.867-0.924) | 79.1 | 88.1 | _ |
p=1/{1+exp[-(-4.7175+0.28*X+0.17*Y+0.50*Z)]} x: CEA(ng/ml) Y: S100A9(ng/ml) Z:TNC(ng/ml)