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. 2019 Aug 29;10(22):5557–5566. doi: 10.7150/jca.35380

Figure 1.

Figure 1

AZGP1 is highly expressed in colorectal cancer tissues with liver metastasis, and high AZGP1expression in tumor tissues indicates a worse prognosis. (A) mRNA expression of AZGP1 was verified by qPCR(n=15,P=0.0034).SLM: Simultaneous liver metastases, MLM: Metachronous liver metastases. (B) Protein expression of AZGP1 was examined by IHC. AZGP1 IHC staining score was higher in tumor tissues than in normal tissues, besides, it was significantly higher in subjects with liver metastasis than those without. N: normal; T: tumor; NLM: normal with liver metastasis; TLM: tumor with liver metastasis (C) Representative images of IHC staining intensity: (-) no staining; (+) weak staining; (++) moderate staining; (+++) strong staining. Scale bar: 25µm. (D) Kaplan-Meier survival curve of AZGP1 expression in tumor tissues from CRC patients after primary tumor resection. HR: hazard ratio; CI: confidence interval; P value: log-rank test. *P<0.05, **P<0.01, ***P<0.001.