Table 4.

Relationships between Ki-67/MKI67 expression and clinicopathological parameters

					Heterogeneity test			Publication bias
Clinicopathological features	Number of studies	Number of patients	OR (95% CI)	P value	I² (%)	P value	Model	Begg's P	Egger's P
Gender	20	2574	1.00 (0.84-1.19)	0.986	0	0.541	Fixed-effects model	0.074	0.387
TNM Stage	20	2452	1.93 (1.34-2.78)	<0.0001	72.4	<0.0001	Random-effects model	0.27	0.253
Tumor differentiation	21	2669	1.94 (1.32-2.85)	0.001	72.7	<0.0001	Random-effects model	0.08	0.487
Lymph node metastasis	25	3439	1.67 (1.23-2.25)	0.001	68.3	<0.0001	Random-effects model	0.207	0.317
Distant metastasis	9	1557	1.67 (1.24-2.26)	0.001	1.7	0.42	Fixed-effects model	0.99	0.6
Invasion depth	16	1695	1.98 (1.60-2.44)	<0.0001	20.4	0.211	Fixed-effects model	0.322	0.341
Lauren's classification	10	1602	1.21 (0.97-1.53)	0.096	46.3	0.053	Fixed-effects model	0.074	0.155
Vascular invasion	5	1329	1.66 (0.70-3.95)	0.253	72.2	0.006	Random-effects model	0.462	0.31

OR: odds ratio; CI: confidence interval.